There is NO free lunch—and NO miracle drugs

Cancer treatments can have unintended side effects‑‑forever

 

Many of us have had treatments and taken multiple medications for all sorts of cancer related conditions. Many of these common and widely used treatments and meds have significant side effects—as you surely know by now, but were not necessarily aware of at the beginning of treatment. 

Revisiting this has been triggered by my recent bladder procedure (cystoscopy) to remove cancer cells and cauterize ‘bleeders’ from my bladder cystitis. The cancer is a continuation of my prostate cancer and the cystitis was likely caused by radiation therapy I had ten years ago, for prostate cancer diagnosed twelve years ago. I was unaware all these years that radiation could cause such a ‘side effect.’ 

On the medication side, one purpose of clinical trials is to determine if the side effects of the experimental medication is within tolerable limits. No one expects new drugs to be free of side effects but, in fact, different people have different levels of unintended results. If the side effect is worse than the disease the FDA won’t approve it (probably). I have had many medication side effects. My list of med side effects has included loss of body hair, growth of hair on my head, significant breast growth, joint pains, hot flashes, upset stomach, fatigue, etc. My wife says ‘crankiness’ is another side effect. 

Treatments such as Chemo and Radiation kill all the bad cells and all the good cells they come in contact with. The ‘bad’ (cancer) cells are supposed to stay dead and the ‘good’ cells are supposed to grow back, mostly. That works often enough for these treatments to be used regularly. These treatments may help, or not. But there will likely be side effects. In my case the radiation did not work and the long-term side effects have been significant. I probably should have done my ‘homework’ a little better and a little sooner.

Pills and injections are less traumatic treatments but if you read the fine print that comes with your prescription, you are at risk some for every disease and condition known to medical science. I take pills to counteract the side effect of other pills. You may be doing the same thing. Why do we do it over and over? It all has to do with our quest to stay alive a little longer.

Of course I will continue to undergo treatments, take pills, and have injections in the hope that I will stay alive and be able to manage the side effects…just a little longer. I also pledge to do more and better homework so I know what to expect.

axman

2012—Will THIS be the Year of the Prostate Cancer Cure?

Probably not, but...

For several years now, there has been progress in finding treatments that lengthen life and reduce side effects for guys with prostate cancer. Much of the research has focused on late-stage cancer. The improvements have been positive--but modest.

There will be an increased focus on a relatively new approach‑‑cancer vaccines‑‑in 2012. These are targeted injections that stimulate your own immune system to identify and kill specific cancer cells. The new vaccines will work much like the vaccines you have already had for smallpox, measles, and other common diseases. Some new vaccines in clinical trials have worked pretty well for some people with some cancers and a new vaccine, Provenge, has been approved to treat late-stage prostate cancer. There is a proven survival benefit—it’s not a cure.

Historically, some major treatments for prostate cancer have depressed (weakened) the immune system—radiation and chemotherapy are good examples. They are also known for their unpleasant side effects. A successful prostate cancer vaccine would do the opposite—strengthen your immune system and build antibodies that would be protective in the future. There would probably be few side effects. Sounds good, doesn’t it! Want to know more about cancer vaccines? Check out the National Cancer Institute.

But there’s a long way to go; even the successful vaccines don’t help everybody equally. I’m optimistic! Good luck to all us guys!

axman

When the Meds Quit Working

You never know when it’s going to happen – but it will

It was a long seven years ago when I was diagnosed with prostate cancer. For the first year or two I was confident that I would be cured. My doctors were optimistic and all but guaranteed success with my prostatectomy and later with external beam radiation. But it came back. And there were no more surefire cures to try.

Next was a clinical trial – but I had to wait until my PSA was high enough to qualify – had to get unhealthier. The pill I took turned out to be about as effective as a sugar pill – but it didn’t taste as good. And my PSA just kept edging up. Five years into my cancer I started low-dose hormone pills and they kept my PSA at bay pretty well for a couple years. Now I’m taking slightly higher doses of hormones. I am happy that my PSA has been creeping up and not leaping up.

So what happens when the hormone pills don’t work any more (and that time WILL come)? I suppose I’ll get newer and more expensive meds to see if they help. Then there’s always chemo (I have too much hair anyway). With any luck I’ll keep trying newer and more exotic treatments until I’m about 90 and then somebody will finally find a cure. It could happen! The shock of that would probably give me a fatal heart attack.

axman